The overseas demand for Chinese TiO2 rose up by about 17% in 2016, which enabled an export increase of the manufacturers in China. As a fact, Chinese TiO2 is highly demanded in overseas markets, due to the comparable small price of the suppliers. The export of TiO2 is responsible for about one-third of the total output in China.

Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO₂ NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO₂ NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.